Estudiantes vs Flamengo Rio de Janeiro: prediction & betting odds 26 September 2025

The second leg of the 2025 Copa Libertadores quarter-final between Estudiantes (Argentina) and Flamengo (Brazil) will take place on September 26 at the Jorge Luis Hirschi Stadium in La Plata. The first match ended with a 2-1 victory for Flamengo. Estudiantes vs. Flamengo: prediction and betting odds, statistics.

Estudiantes

In the first leg, Eduardo Dominguez's team lost away, marking only their third defeat in the last ten Copa Libertadores matches. However, the deficit is minimal, and the club still has a good chance to continue their quest for the trophy. A victory by one goal in the return leg would lead to a penalty shootout, while a larger win would send Estudiantes to the semi-finals. However, in their last 13 Copa Libertadores matches, the team has only managed five wins against six losses. It's worth noting that the Argentines have not surpassed the quarter-final stage in this tournament since the 2008/09 season, when Estudiantes won the Copa Libertadores.

  • Estudiantes have scored in 10 of their last 11 Copa Libertadores matches.
  • The Argentines have kept a clean sheet in 5 of their last 7 games in this tournament.
  • At least 2 goals have been scored in 8 of Estudiantes' last 11 Copa Libertadores encounters.

Predicted lineup for Estudiantes (4-2-3-1)

Fernando Muslera – Roman Gomez, Santiago Nunez, Facundo Rodriguez, Santiago Arzamendia – Ezequiel Piovi, Mikel Amondarain – Santiago Ascacibar, Cristian Medina, Facundo Farias – Guido Carrillo.

Key defenders Leandro Gonzalez Pirez and Eric Mesa are unavailable due to injury. Forward Edwin Setre is also sidelined for the same reason.

Flamengo

By winning the first match against Estudiantes, the Brazilians secured their fifth consecutive victory in the Copa Libertadores. Although they couldn't keep a clean sheet, having not conceded in the previous four tournament matches, Flamengo's scoring streak in the Copa Libertadores has now reached six games. To advance to the semi-finals, the club simply needs to avoid defeat in regular time, and it's worth noting that the Brazilians have not lost in their last seven Copa Libertadores matches (5 wins, 2 draws). If the team reaches the semi-finals, it will be for the first time since 2022, when Flamengo claimed the title by defeating Atletico Paranaense.

  • The Brazilians have won with a handicap (+1.5) in their last 19 Copa Libertadores encounters.
  • No more than 2 goals have been scored in 6 of the club's last 7 matches in this tournament.
  • At least one team has failed to score in 13 of Flamengo's last 16 Copa Libertadores games.

Predicted lineup for Flamengo (4-2-3-1)

Agustin Rossi – Guillermo Varela, Leo Ortiz, Leo Pereira, Ayrton Lucas – Nicolas De La Cruz, Saul Niguez – Gonzalo Plata, Giorgian De Arrascaeta, Samuel Lino – Johnny Cardinoti Pedro.

Main forward Gonzalo Plata is suspended.

Referee

Piero Maza (Chile)

Matches – 12 (International matches, 2025);

Yellow cards shown (including second yellows) – 55;

Average yellow cards per match – 4.6;

Red cards shown – 1;

Average fouls per match – 22;

Penalties – 25%.

Estudiantes vs. Flamengo: Match Prediction

Flamengo proved stronger in the first leg, achieving their fifth consecutive Copa Libertadores victory. However, it's important to note that four of these five victories occurred at home. Playing away, the team typically doesn't appear as formidable as they do on their home turf. This is evidenced by the fact that Flamengo has not won in 11 of their last 13 away Copa Libertadores matches (6 draws, 5 losses). The Brazilians would be satisfied with a draw, so they are likely to adopt a cautious approach.

Estudiantes, as the home team, will also try to maximize their home-field advantage. The Argentines have not lost in 12 of their last 16 home Copa Libertadores matches, scoring at least one goal in 13 of those games, with 11 ending in victory. Their home unbeaten streak in the Copa Libertadores stands at three matches, each of which Estudiantes played to a clean sheet.

While it's uncertain whether the hosts will secure a spot in the tournament's semi-finals, avoiding another defeat in regular time is within their reach. Prediction – "Estudiantes to win or draw"

Estudiantes vs Flamengo Rio de Janeiro Odds

1X2
DOUBLE CHANCE
OVER/UNDER
BTTS
TOTAL HOME GOALS
TOTAL AWAY GOALS
Bookie1X2

Current season

Logo Estudiantes Logo Flamengo
4 Wins 3
2 Lost 1
0 Draws 2
1.44 GF per game 1.14
0.78 GA per game 0.57
5.11 Corners per game 5.86
2.78 Yellow cards per game 2.14

Copa Libertadores: previous matches in the tournament

Estudiantes
19.09.25
Flamengo Rio de Janeiro
Estudiantes
L
20.08.25
Estudiantes
Cerro Porteño
D
13.08.25
Cerro Porteño
Estudiantes
W
28.05.25
Estudiantes
Carabobo FC
W
15.05.25
Botafogo
Estudiantes
L
08.05.25
Club Universidad de Chile
Estudiantes
W
24.04.25
Estudiantes
Botafogo
W
09.04.25
Estudiantes
Club Universidad de Chile
L
01.04.25
Carabobo FC
Estudiantes
W
More matches
Flamengo Rio de Janeiro
19.09.25
Flamengo Rio de Janeiro
Estudiantes
W
21.08.25
Internacional
Flamengo Rio de Janeiro
W
14.08.25
Flamengo Rio de Janeiro
Internacional
W
29.05.25
Flamengo Rio de Janeiro
Deportivo Táchira
W
16.05.25
Flamengo Rio de Janeiro
LDU Quito
W
08.05.25
Flamengo Rio de Janeiro
D
22.04.25
LDU Quito
Flamengo Rio de Janeiro
D
10.04.25
Flamengo Rio de Janeiro
L
04.04.25
Deportivo Táchira
Flamengo Rio de Janeiro
W
More matches

H2H: Estudiantes — Flamengo Rio de Janeiro

Copa Libertadores 2025
19.09.25
Flamengo Rio de Janeiro
Estudiantes

Group stage

CONMEBOL Libertadores: Group C
Team
Played
Matches played
W
D
L
Goals
G
Points
P
1
LDU Quito
  0:0 2:0 6 3 2 1
8:4
11
2
Flamengo Rio de Janeiro
2:0   1:0 6 3 2 1
6:3
11
3
Deportivo Táchira
2:3 0:1   6 0 0 6
4:11
0

Team lineups

The line-ups will be known a few hours before kick-off
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