Inter Milan vs Sassuolo: prediction & betting odds 21 September 2025

The Matchday 4 clash in Serie A between Inter and Sassuolo will take place on September 21 at the San Siro Stadium in Milan. Inter vs. Sassuolo: prediction and betting odds, statistics.

Inter

Christian Chivu's side suffered a 3-4 defeat away to Juventus in the last round. Inter had the lead during the match but conceded two goals after the 80th minute, resulting in their second consecutive loss in Serie A. Notably, the team has scored at least three goals in a match for the second time this season. Despite leading the league in goals scored (9), Inter sits 11th in the standings with three points.

  • The club has won 8 of their last 11 home matches in Serie A.
  • At least three goals have been scored in 6 of their last 8 home league games.
  • Inter has conceded in 6 of their last 8 home matches in Serie A.

Predicted lineup for Inter (3-5-2)

Yann Sommer – Manuel Akanji, Francesco Acerbi, Alessandro Bastoni – Denzel Dumfries, Henrikh Mkhitaryan, Nicolo Barella, Hakan Calhanoglu, Carlos Augusto – Lautaro Martinez, Marcus Thuram.

Sassuolo

In the last round, Fabio Grosso's side defeated Lazio 1-0 at home. This victory marked Sassuolo's first win of the current Serie A season, ending a five-match winless streak in the Italian top flight (1 draw, 4 losses). Additionally, the team kept a clean sheet for only the second time in their last 13 Serie A matches. Sassuolo has three points and is 14th in the standings.

  • The club has lost 10 of their last 12 away matches in Serie A.
  • Both teams scored in the last five away matches in the league.
  • Sassuolo conceded exactly 1 or 2 goals in 5 of their last 7 away Serie A matches.

Predicted lineup for Sassuolo (4-3-3)

Arijanet Muric – Josh Doig, Tarik Muharemovic, Jay Idzes, Sebastian Walukiewicz – Nemanja Matic, Ismael Kone, Aster Vranckx – Armand Lauriente, Andrea Pinamonti, Domenico Berardi.

Referee

Livio Marinelli (Italy)

Matches – 17 (Serie A, 2024/25–2025/26);

Yellow cards shown (including second yellows) – 49;

Average yellow cards per match – 2.9;

Red cards shown – 3;

Average fouls per match – 23;

Penalties – 24%.

Inter vs. Sassuolo: Match Prediction

Christian Chivu's charges started the current championship with a convincing 5-0 win over Torino, but subsequently lost two consecutive matches, conceding a total of six goals. Moreover, Inter's defense has been unreliable at home recently, keeping only two clean sheets in their last eight Serie A home games.

In the current championship, Sassuolo has already scored two goals in an away game against Cremonese, and the team has been effective offensively in recent outings, scoring in five of their last away matches in the Italian top flight. Additionally, Sassuolo has found the net in their last five encounters with Inter at San Siro, scoring ten goals in that span.

I expect at least one goal from the visitors, so my prediction: Sassuolo individual total over 0.5

Inter Milan vs Sassuolo Odds

Current season

Logo Internazionale Logo Sassuolo
1 Wins 1
2 Lost 2
3 GF per game 1
2 GA per game 1.67
9.33 Corners per game 2.67
0.67 Yellow cards per game 3.33

Serie A: previous matches in the tournament

Inter Milan
13.09.25
Juventus
Inter Milan
L
31.08.25
Inter Milan
Udinese
L
25.08.25
Inter Milan
Torino
W
More matches
Sassuolo
14.09.25
Sassuolo
Lazio
W
29.08.25
Cremonese
Sassuolo
L
23.08.25
Sassuolo
Napoli
L
More matches

H2H: Inter Milan — Sassuolo

Serie A 2023-2024
04.05.24
Sassuolo
Inter Milan
27.09.23
Inter Milan
Sassuolo
Serie A 2022-2023
13.05.23
Inter Milan
Sassuolo
08.10.22
Sassuolo
Inter Milan
Serie A 2021-2022
20.02.22
Inter Milan
Sassuolo
02.10.21
Sassuolo
Inter Milan
Serie A 2020-2021
07.04.21
Inter Milan
Sassuolo
28.11.20
Sassuolo
Inter Milan
Serie A 2019-2020
24.06.20
Inter Milan
Sassuolo
20.10.19
Sassuolo
Inter Milan
Serie A 2018-2019
19.01.19
Inter Milan
Sassuolo
19.08.18
Sassuolo
Inter Milan
Serie A 2017-2018
12.05.18
Inter Milan
Sassuolo
23.12.17
Sassuolo
Inter Milan
Serie A 2016-2017
14.05.17
Inter Milan
Sassuolo
18.12.16
Sassuolo
Inter Milan
Serie A 2015-2016
14.05.16
Sassuolo
Inter Milan
10.01.16
Inter Milan
Sassuolo
Serie A 2014-2015
01.02.15
Sassuolo
Inter Milan
14.09.14
Inter Milan
Sassuolo
Serie A 2013-2014
08.02.14
Inter Milan
Sassuolo
1
:
0
21.09.13
Sassuolo
Inter Milan
0
:
7
More matches

Tables

Team Played W D L Goals Points Form
1
Napoli
3 3 0 0 6:1 9
2
Juventus
3 3 0 0 7:3 9
3
Cremonese
3 2 1 0 5:3 7
4
Udinese
3 2 1 0 4:2 7
5
Cagliari
4 2 1 1 5:3 7
6
AC Milan
3 2 0 1 4:2 6
7
AS Roma
3 2 0 1 2:1 6
8
Atalanta
3 1 2 0 6:3 5
9
Como
3 1 1 1 3:2 4
10
Torino
3 1 1 1 1:5 4
11
Inter Milan
3 1 0 2 9:6 3
12
Lazio
3 1 0 2 4:3 3
13
Bologna
3 1 0 2 1:2 3
14
Sassuolo
3 1 0 2 3:5 3
15
Genoa
3 0 2 1 1:2 2
16
Fiorentina
3 0 2 1 2:4 2
17
Hellas Verona
3 0 2 1 1:5 2
18
Pisa
3 0 1 2 1:3 1
19
Parma
3 0 1 2 1:5 1
20
Lecce
4 0 1 3 2:8 1
Team Played W D L Goals Points Form
1
Juventus
2 2 0 0 6:3 6
2
Cagliari
2 1 1 0 3:1 4
3
Atalanta
2 1 1 0 5:2 4
4
Como
2 1 1 0 3:1 4
5
Napoli
1 1 0 0 1:0 3
6
Cremonese
1 1 0 0 3:2 3
7
AC Milan
2 1 0 1 2:2 3
8
AS Roma
2 1 0 1 1:1 3
9
Inter Milan
2 1 0 1 6:2 3
10
Lazio
1 1 0 0 4:0 3
11
Bologna
1 1 0 0 1:0 3
12
Sassuolo
2 1 0 1 1:2 3
13
Udinese
1 0 1 0 1:1 1
14
Torino
1 0 1 0 0:0 1
15
Genoa
2 0 1 1 0:1 1
16
Hellas Verona
1 0 1 0 0:0 1
17
Parma
1 0 1 0 1:1 1
18
Fiorentina
1 0 0 1 1:3 0
19
Pisa
2 0 0 2 0:2 0
20
Lecce
2 0 0 2 1:4 0
Team Played W D L Goals Points Form
1
Napoli
2 2 0 0 5:1 6
2
Udinese
2 2 0 0 3:1 6
3
Cremonese
2 1 1 0 2:1 4
4
Juventus
1 1 0 0 1:0 3
5
Cagliari
2 1 0 1 2:2 3
6
AC Milan
1 1 0 0 2:0 3
7
AS Roma
1 1 0 0 1:0 3
8
Torino
2 1 0 1 1:5 3
9
Fiorentina
2 0 2 0 1:1 2
10
Atalanta
1 0 1 0 1:1 1
11
Genoa
1 0 1 0 1:1 1
12
Hellas Verona
2 0 1 1 1:5 1
13
Pisa
1 0 1 0 1:1 1
14
Lecce
2 0 1 1 1:4 1
15
Como
1 0 0 1 0:1 0
16
Inter Milan
1 0 0 1 3:4 0
17
Lazio
2 0 0 2 0:3 0
18
Bologna
2 0 0 2 0:2 0
19
Sassuolo
1 0 0 1 2:3 0
20
Parma
2 0 0 2 0:4 0

Team lineups

The line-ups will be known a few hours before kick-off
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