Liverpool vs Southampton: prediction & betting odds 23 September 2025

The English League Cup Round of 16 match between Liverpool and Southampton will take place on September 23 at Anfield. Liverpool vs. Southampton: prediction and betting odds, statistics.

Liverpool

Arne Slot's side, like other teams in the European competition zone, are starting in the Cup only from this round. Last season, the team reached the final but lost to Newcastle 1-2. It is also worth noting that since 2022, Liverpool has won this tournament twice more (both times defeating Chelsea in the final).

  • The club has suffered only 2 defeats in regular time in their last 12 games in this tournament (8 wins and 2 draws).
  • At least 3 goals were scored in 90 minutes in 5 of Liverpool's last 6 League Cup encounters.
  • Both teams scored in regular time in 10 of Liverpool's last 12 matches in this tournament.

Predicted lineup for Liverpool (3-4-3)

Alisson Becker – Milos Kerkez, Ibrahima Konate, Virgil van Dijk – Alexis Mac Allister, Dominik Szoboszlai, Cody Gakpo, Ryan Gravenberch – Mohamed Salah, Florian Wirtz, Hugo Ekitike.

Southampton

The team has already gone through two stages. Playing away, the club secured clean-sheet victories over two opponents: Northampton Town (1-0) and Norwich (3-0). Last season, Southampton reached the quarter-finals, where they lost at home to Liverpool 1-2. It's also worth mentioning that in 2017 the team reached the League Cup final, and in 2023 they made it to the semi-finals.

  • In the last six encounters in this tournament, the club has suffered only 1 defeat in regular time (4 wins and 1 draw).
  • Both teams scored in 90 minutes in 6 of Southampton's last 8 League Cup matches.
  • At least 3 goals were scored in regular time in 6 of the team's last 8 games in this tournament.

Predicted lineup for Southampton (4-2-3-1)

Gavin Bazunu – Jack Stephens, Taylor Harwood-Bellis, Ryan Manning, Mads Roerslev – Shea Charles, Flynn Downes – Ryan Fraser, Finn Azaz, Tom Fellows – Cameron Archer.

Liverpool vs. Southampton: Match Prediction

Liverpool has an excellent record against this opponent. In the last 9 official meetings, Liverpool has secured 8 wins and 1 draw. However, they have only won by a margin of 4 or more goals once in the last 10 head-to-head encounters in the Premier League and two national cups.

Considering their commitments in the Champions League and Premier League, Arne Slot will rotate his squad, allowing us to see young talents and bench players in this match. This will help the visitors avoid a heavy defeat. Moreover, in their last 21 matches in this tournament, Liverpool has only achieved 2 wins with a margin of 4 or more goals. Meanwhile, Southampton has not lost by a large margin in 30 consecutive matches in this tournament.

My prediction – Southampton with a handicap (+3)

Liverpool vs Southampton Odds

EFL Cup: previous matches in the tournament

Liverpool
The team hasn't played a game yet this season
Southampton
26.08.25
Norwich
Southampton
W
12.08.25
Northampton Town
Southampton
W
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H2H: Liverpool — Southampton

Premier League 2024-2025
08.03.25
Liverpool
Southampton
EFL Cup 2024-2025
18.12.24
Southampton
Liverpool
Premier League 2024-2025
24.11.24
Southampton
Liverpool
FA Cup 2023-2024
28.02.24
Liverpool
Southampton
Premier League 2022-2023
28.05.23
Southampton
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12.11.22
Liverpool
Southampton
Premier League 2021-2022
17.05.22
Southampton
Liverpool
27.11.21
Liverpool
Southampton
Premier League 2020-2021
08.05.21
Liverpool
Southampton
04.01.21
Southampton
Liverpool
Premier League 2019-2020
01.02.20
Liverpool
Southampton
17.08.19
Southampton
Liverpool
Premier League 2018-2019
05.04.19
Southampton
Liverpool
22.09.18
Liverpool
Southampton
Premier League 2017-2018
11.02.18
Southampton
Liverpool
18.11.17
Liverpool
Southampton
Premier League 2016-2017
07.05.17
Liverpool
Southampton
19.11.16
Southampton
Liverpool
Premier League 2015-2016
20.03.16
Southampton
Liverpool
25.10.15
Liverpool
Southampton
Premier League 2014-2015
22.02.15
Southampton
Liverpool
17.08.14
Liverpool
Southampton
Premier League 2013-2014
28.02.14
Southampton
Liverpool
0
:
3
20.09.13
Liverpool
Southampton
0
:
1
Premier League 2012-2013
15.03.13
Southampton
Liverpool
3
:
1
30.11.12
Liverpool
Southampton
1
:
0
Premier League 2004-2005
21.01.05
Southampton
Liverpool
2
:
0
27.12.04
Liverpool
Southampton
1
:
0
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Team lineups

The line-ups will be known a few hours before kick-off
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